Polyclonal Antibody to GSK3 Alpha/beta (Phospho-Tyr279/216)
Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13; 137 (1-2) : 193-201 Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02; 316 (2) : 411-415 Fan G, et al. J Biol Chem 2003 Dec 26; 278 (52) : 52432-52436 Liao X, et al. Mol Cancer Ther 2003 Nov; 2 (11) : 1215-1222
Product Specifications
Product Name Alternative
Factor A|| GSK-3 alpha/beta|| kinase GSK3-alpha/beta
Gene Name
GSK3A
Gene ID
2931
UniProt
P49840/P49841
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around phosphorylation site of tyrosine 279/216 (V-S-Y (p) -I-C) derived from Human GSK3 alpha/beta.
Target Antigen
GSK3 Alpha/ Beta (Phospho-Tyr279/216)
Clonality
Polyclonal
Applications
IHC, WB, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 46, 51kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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