Polyclonal Antibody to PKR (Phospho-Thr446)
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. Abujiang Pataer, et, al. (2002) Cancer Res; 62: 2239. K. D. Ryman, et, al. (2005) J. Virol; 79: 1487 - 1499. Susana Guerra, et, al. (2006) J. Biol. Chem; 281: 18734 - 18745.
Product Specifications
Product Name Alternative
ADRB2|| E2AK2|| EIF2AK2|| EIF2aK|| PRKR
Gene Name
EIF2AK2
Gene ID
5610
UniProt
P19525
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of threonine 446 (K-R-T (p) -R-S) derived from Human PKR.
Target Antigen
PKR (Phospho-Thr446)
Clonality
Polyclonal
Applications
WB, IHC, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 68kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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