Polyclonal Antibody to p56Dok-2 (Phospho-Tyr299)
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation Feng Cong, et, al. (1999) Mol. Cell. Biol ; 19: 8314 - 8325. Serge Lemay, et, al. (2000) Mol. Cell. Biol ; 20: 2743 - 2754. Ute Schaeper, et, al. (2000) J. Cell Biol ; 149: 1419. Miyuki Honma, et, al. (2006) Genes Cells; 11: 143 - 151.
Product Specifications
Product Name Alternative
DOK2
Gene Name
DOK2
Gene ID
9046
UniProt
O60496
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of tyrosine 299 (G-E-Y (p) -A-V) derived from Human p56Dok-2.
Target Antigen
P56Dok-2 (Phospho-Tyr299)
Clonality
Polyclonal
Applications
WB, IHC, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 56kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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