Polyclonal Antibody to p62Dok (phospho-Tyr362)
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. Zhou Songyang, et al. (2001) J. Biol. Chem ; 276: 2459 - 2465. Jean-Guy N
Product Specifications
Product Name Alternative
DOK1
Gene Name
DOK1
Gene ID
1796
UniProt
Q99704
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around phosphorylation site of tyrosine 362 (P-I-Y (p) -D-E) derived from Human p62Dok.
Target Antigen
P62Dok (phospho-Tyr362)
Clonality
Polyclonal
Applications
WB, IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 62kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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