Polyclonal Antibody to Cortactin (Phospho-Tyr466)

Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. Luo C, et al. (2006) J Biol Chem ; 281 (40) :30081-30093 Head JA, et al. (2003) Mol Biol Cell ;14 (8) :3216-3229 Li Y, et al. (2000) J Biol Chem ; 275 (47) : 37187-37193 Kinley AW, et al. (2003) Curr Biol ; 13 (5) : 384-393