Polyclonal Antibody to Merlin (Phospho-Ser518)
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Guang-Hui Xiao, et al. (2005) Mol. Cell. Biol ; 25: 2384 - 2394. Hi-Su Yang, et al. (2006) Cancer Res ; 66: 2708 - 2715. R Bohni, et al. (1994) J. Biol. Chem ; 269: 14541 - 14545. Adam J. Ratner, et al. (2001) J. Biol. Chem ; 276: 19267 - 19275.
Product Specifications
Product Name Alternative
MERL|| NF2|| Neurofibromin 2|| SCH|| Schwannomerlin
Gene Name
NF2
Gene ID
4771
UniProt
P35240
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around phosphorylation site of serine 518 (R-L-S (p) -M-E) derived from Human Merlin.
Target Antigen
Merlin (Phospho-Ser518)
Clonality
Polyclonal
Applications
WB, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 69kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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