Polyclonal Antibody to Alpha-Synuclein (Phospho-Tyr125)
SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43) : 42225-33 Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14) : 12334-42 Negro A, et al. FASEB J 2002 Feb; 16 (2) : 210-2 Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.
Product Specifications
Product Name Alternative
NACP|| SYN|| SYUA|| alpha-synuclein
Gene Name
SNCA
Gene ID
6622
UniProt
P37840
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of tyrosine 125 (E-A-Y (p) -E-M) derived from Human a-Synuclein.
Target Antigen
Alpha-Synuclein (Phospho-Tyr125)
Clonality
Polyclonal
Applications
WB, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 18kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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