Polyclonal Antibody to P38 MAPK (Phospho-Thr180)
Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis. Kim JE, et al. (2005) J Proteome Res Jul-Aug; 4 (4) : 1339-1346 Meng F, et al. (2005) Am J Physiol Cell Physiol May 25 Jin ZH, et al. (2005) Oncogene Mar 17; 24 (12) : 1973-1981
Product Specifications
Product Name Alternative
MAPK2|| MAPKAPK-2|| MAPKAPK2
Gene Name
MAPK14
Gene ID
1432
UniProt
Q16539
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around phosphorylation site of threonine 180 (E-M-T (p) -G-Y) derived from Human P38MAPK.
Target Antigen
P38 MAPK (Phospho-Thr180)
Clonality
Polyclonal
Applications
WB, IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 43kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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