Polyclonal Antibody to 4E-BP1 (Phospho-Thr45)

4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. Gingras AC, et al. (1998) Genes Dev 12 (4) : 502-513. Brugarolas J, et al. (2004) Genes Dev 18 (23) : 2893-2904. Kumar V, et al. (2000) EMBO J 19 (5) : 1087-1097. Moody CA, et al. (2005) J Virol 79 (9) : 5499-5506. Burnett PE, et al. (1998) Proc Natl Acad Sci U S A 95 (4) : 1432-1437.