Polyclonal Antibody to APP (Phospho-668)
APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy) . Multiple transcript variants encoding several different isoforms have been found for this gene. Hung, A.Y. and Selkoe, D.J. (1994) EMBO J. 13, 534-542. Suzuki, T. et al. (1994) EMBO J. 13, 1114-1122 Ando, K. et al. (1999) J. Neurosci. 19, 4421-4427. Iijima, K.I. et al. (2000) J. Neurochem. 75, 1085-1091
Product Specifications
Product Name Alternative
AAA|| AD1|| PN2|| ABPP|| APPI
Gene Name
APP
Gene ID
351
UniProt
P05067
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around phosphorylation site of threonine 668 (A-V-T (p) -P-E) derived from Human APP.
Target Antigen
APP (Phospho-668)
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 100-140 kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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