Polyclonal Antibody to EGFR (Phospho-Thr678)
Receptor for EGF, but also for other members of the EGF family, as TGF-a, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin. Doherty JK, et al. (1999) Proc Natl Acad Sci U S A; 96 (19) : 10869-10874 Wu TT, et al. (1998) Mol Biol Cell; 9 (7) : 1661-1674 O
Product Specifications
Product Name Alternative
ERBB1|| Receptor protein-tyrosine kinase ErbB-1|| kinase EGFR
Gene Name
EGFR
Gene ID
1956
UniProt
P00533
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around phosphorylation site of threonine 678 (K-R-T (p) -L-R) derived from Human EGFR.
Target Antigen
EGFR (Phospho-Thr678)
Clonality
Polyclonal
Applications
WB, IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 175kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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