AMPK Alpha1 (Phospho-Ser487) Polyclonal Antibody
Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. Kim JE, et al. (2005) J Proteome Res. 4 (4) : 1339-1346. Woods A, et al. (2003) J Biol Chem. 278 (31) : 28434-28442.
Product Specifications
Product Name Alternative
AAPK1|| AMPK alpha-1 chain|| AMPK-alpha1|| HMG-CoA redustase kinase|| PRKAA1
Gene Name
PRKAA1
Gene ID
5562
UniProt
Q13131/P54646
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of serine 496 (S-G- S (P) -V-S) derived from Human AMPK?1.
Target Antigen
AMPK Alpha1 (Phospho-Ser487) Antibody
Clonality
Polyclonal
Applications
WB, IHC, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 63kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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