Polyclonal Antibody to MEK1 (Phospho-Ser221)
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases. Zebisch A, et al. (2006) Cancer Res; 66 (7) : 3401-8. Luciano BS, et al. (2006) J Biol Chem; 279 (50) : 52117-23. Wang X, et al. (2003) Oncogene; 22 (1) : 109-16. Gopalbhai K, et al. (2003) J Biol Chem; 278 (10) : 8118-25. Ling MT, et al. (2002) Oncogene; 21 (55) : 8498-505.
Product Specifications
Product Name Alternative
ERK activator kinase 1|| MAP kinase kinase 1|| MAP2K1|| MAPK/ERK kinase 1|| MAPKK 1
Gene Name
MAP2K1
Gene ID
5604
UniProt
Q02750
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around phosphorylation site of serine 221 (A-N-S (p) -F-V) derived from Human MEK1.
Target Antigen
MEK1 (Phospho-Ser221)
Clonality
Polyclonal
Applications
WB, IHC, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 45kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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