Polyclonal Antibody to Zap-70 (Phospho-Tyr319)
Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not. Salomon AR, et al. (2003) Proc Natl Acad Sci U S A; 100 (2) : 443-448 Ku GM, et al. (2001) EMBO J; 20 (3) : 457-465 Tang J, et al. (1999) Proc Natl Acad Sci U S A; 96 (17) : 9775-9780 Zhao Q, et al. (1996) Mol Cell Biol; 16 (12) : 6765-6774 Williams BL, et al. (1999) EMBO J; 18 (7) : 1832-1844 Adjali O, et al. (2005) J Clin Invest; 115 (8) : 2287-2295.
Product Specifications
Product Name Alternative
SRK||STD||TZK||STCD||ZAP-70
Gene Name
ZAP70
Gene ID
7535
UniProt
P43403
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around phosphorylation site of tyrosine 319 (S-P-Y (p) -S-D) derived from Human Zap-70.
Target Antigen
Zap-70 (Phospho-Tyr319)
Clonality
Polyclonal
Applications
WB, IHC, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 70kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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