Polyclonal Antibody to IkB- Alpha (Phospho-Ser32/Ser36)
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
Product Specifications
Product Name Alternative
I-kappa-B-alpha, IKBA, NF-kappaB inhibitor alpha, NF-KBI, NF-KBIA
Gene Name
NF-KBIA
Gene ID
4792
UniProt
P25963
Host
Rabbit
Reactivity
Mouse, Human
Immunogen
Peptide sequence around phosphorylation site of serine 32/36 (H-D-S (p) -G-L-D-S (p) -M-K) derived from Human IkB-a.
Target Antigen
I?B- Alpha (Phospho-Ser32/Ser36)
Clonality
Polyclonal
Applications
IHC, WB, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 39kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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