Polyclonal Antibody to TYK2 (Phospho-Tyr1054)
TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. Zheng H, et al. (2005) Mol Cell Proteomics. 4 (6) :721-730. Gauzzi MC, et al. (1996) J Biol Chem. 271 (34) : 20494-20500.
Product Specifications
Product Name Alternative
Tyrosine kinase 2|| JTK1
Gene Name
TYK2
Gene ID
7297
UniProt
P29597
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around phosphorylation site of tyrosine 1054 (H-E-Y (p) -Y-R) derived from Human TYK2.
Target Antigen
TYK2 (Phospho-Tyr1054)
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 140kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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