Polyclonal Antibody to IKK Alpha (Phospho-Thr23)

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NF-KB2/p100 associated with RelB, inducing its proteolytic processing to NF-KB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines. Yuan ZQ, et al. (2002) J Biol Chem; 277 (33) : 29973-82. Ozes ON, et al. (1999) Nature; 401 (6748) : 82-5.