Polyclonal Antibody to Tau (Phospho-Ser404)
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Li G, Yin H, et.al . (2004) J Biol Chem ; 279 (16) : 15938-45. Noble W, et al. (2003) Neuron ; 38 (4) : 555-65. Giasson BI, et al. (2002) . Biochemistry; 41 (51) : 15376-87. Lee G., et.al. (1989) . Neuron 2:1615-1624. Andreadis A.et.al. (1992) Biochemistry 31:10626-10633.
Product Specifications
Product Name Alternative
MAPT|| MTAPT|| MTBT1|| Neurofibrillary tangle protein|| PHF-tau
Gene Name
MAPT
Gene ID
4137
UniProt
P10636
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around phosphorylation site of serine 404 (D-T-S (p) -P-R) derived from Human Tau.
Target Antigen
Tau (Phospho-Ser404)
Clonality
Polyclonal
Applications
IHC, WB, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 48 62 78 kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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