Polyclonal Antibody to p53 (Phospho-Ser15)
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Lin T, et al. (2005) Nat Cell Biol; 7 (2) : 165-71. Vega FM, et al. (2004) Mol Cell Biol; 24 (23) : 10366-80. Li J, et al. (2004) J Biol Chem; 279 (40) : 41275-9. Wang J, et al. (2004) J Biol Chem; 279 (38) : 39584-92.
Product Specifications
Product Name Alternative
Tumor suppressor p53|| Phosphoprotein p53|| Antigen NY-CO-13|| TP53
Gene Name
TP53
Gene ID
7157
UniProt
P04637
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of serine 15 (P-L-S (p) -Q-E) derived from Human p53.
Target Antigen
P53 (Phospho-Ser15)
Clonality
Polyclonal
Applications
IHC, WB, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 53kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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