Polyclonal Antibody to ICAM-1 (Phospho-Tyr512)
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin a-L/beta-2) . During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. Greenwood J, et al. (2003) J Immunol; 171 (4) :2099-2108. Zhou Z, et al. (2005) Eur J Pharmacol; 513 (1-2) :1-8. Chen YH, et al. (2001) J Cell Biochem; 82 (3) :512-521
Product Specifications
Product Name Alternative
ICA1|| ICAM1
Gene Name
ICAM1
Gene ID
3383
UniProt
P05362
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of tyrosine 512 (K-K-Y (p) -R-L) derived from Human ICAM-1.
Target Antigen
ICAM-1 (Phospho-Tyr512)
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 89 92kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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