Polyclonal Antibody to BAD (Phospho-Ser136)
The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. Wang XQ, et al. (2001) . J Biol Chem.276 (48) : 44504-44511. Lee YI, et al. (2001) . J Biol Chem.276 (20) : 16969-16977. Maiti D, et al. (2001) . J Biol Chem.276 (1) : 329-333.
Product Specifications
Product Name Alternative
Bbc2
Gene Name
Bad
Gene ID
12015
UniProt
Q61337
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around phosphorylation site of serine136 (S-R-S (p) -A-P) derived from Mouse BAD.
Target Antigen
BAD (Phospho-Ser136)
Clonality
Polyclonal
Applications
WB, IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 23kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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