Polyclonal Antibody to BCL-2 (Phospho-Ser70)
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) .
Product Specifications
Product Name Alternative
Bcl-2|| PPP1R50
Gene Name
BCL2
Gene ID
596
UniProt
P10415
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of serine 70 (R-T-S (p) -P-L) derived from Human BCL-2.
Target Antigen
BCL-2 (Phospho-Ser70)
Clonality
Polyclonal
Applications
IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 26kd, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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