Polyclonal Antibody to Ezrin (Phospho-Tyr353)
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. Zhao H, et al. (2004) Proc Natl Acad Sci U S A101 (25) : 9485-9490. Wang Q, et al. (2003) J Biol Chem 278 (48) : 47731-47743. Gautreau A, et al. (1999) Proc Natl Acad Sci U S A 96 (13) : 7300-7305. Crepaldi T, et al. (1997) J Cell Biol 138 (2) : 423-34.
Product Specifications
Product Name Alternative
Cytovillin|| EZRI|| VIL2|| Villin 2|| p81
Gene Name
EZR
Gene ID
7430
UniProt
P15311
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of tyrosine 353 (Q-D-Y (p) -E-E) derived from Human EZRIN.
Target Antigen
Ezrin (Phospho-Tyr353)
Clonality
Polyclonal
Applications
WB, IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 81kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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