Polyclonal Antibody to MEF2A (Phospho-Thr319)
The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589) ), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain
Product Specifications
Product Name Alternative
MEF2|| Serum response factor-like protein 1
Gene Name
MEF2A
Gene ID
4205
UniProt
Q02078
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around phosphorylation site of Thr319 (V-T-T (p) -P-S) derived from Human MEF2A.
Target Antigen
MEF2A (Phospho-Thr319)
Clonality
Polyclonal
Applications
IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 54kd, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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