Polyclonal Antibody to Raf1 (Phospho-Ser259)
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3. Dougherty M K, et al. (2005) Mol Cell. 17 (2) : 215-224. Hekman M, et al. (2005) FEBS Lett. 579 (2) : 464-468. Avruch J, et al. (1994) Trends Biochem. Sci. 19, 279-283. Chong H, et al. (2001) EMBO J. 20, 3716-3727. King A J, et al. (1998) Nature. 396:180-183.
Product Specifications
Product Name Alternative
C-RAF|| C-Raf|| CRAF
Gene Name
RAF1
Gene ID
5894
UniProt
P04049
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around phosphorylation site of serine 259 (S-T-S (p) -T-P) derived from Human Raf1.
Target Antigen
Raf1 (Phospho-Ser259)
Clonality
Polyclonal
Applications
IHC, WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 73kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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