Anti-Hu CD207 (Clone 2G3) Alexa Fluor 647

CD207 is a 40 kDa type II transmembrane glycoprotein of the C-type lectin family. It binds to mannose-bearing glycoproteins and glycolipids of microbial and viral antigens, including HIV gp120. CD207 is expressed only in Langerhans cells, which are immature dendritic cells of the epidermis and mucosa, and its expression decreases during Langerhans cells maturation. Upon antigen binding CD207 localizes to the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed membranes, which leads to a nonclassical antigen-processing pathway.

Product Specifications

Product Name Alternative

CLEC4K, langerin

Gene Name

CD207

Gene ID

50489

UniProt

Q9UJ71

Host

Mouse

Reactivity

Human, Non-Human Primates

Immunogen

Fusion protein of human CD207 extracellular part and IgG Fc fragment

Target Antigen

CD207

Clonality

Monoclonal

Clone

2G3

Applications

FACS

Purification

Purified by protein-A affinity chromatography.

Components

Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage Conditions

Store at 2-8°C. Do not freeze.

Applications Notes

Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.