APC Conjugated Anti-DLL4 (Clone : MHD4-46)
DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach. Specificity : The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.
Product Specifications
Product Name Alternative
Delta like ligand 4, AOS6, canonical Notch ligand 4, delta like canonical Notch ligand 4
Gene Name
DLL4
Gene ID
54567
UniProt
Q9NR61
Reactivity
Human
Immunogen
Recombinant soluble human DLL4
Target Antigen
DLL4
Clonality
Monoclonal
Clone
MHD4-46
Applications
FACS
Purification
Components
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Isotype
Mouse IgG1 kappa
Conjugate
APC
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