Anti-CD207 Monoclonal Antibody (Clone:2G3)
CD207 is a 40 kDa type II transmembrane glycoprotein of the C-type lectin family. It binds to mannose-bearing glycoproteins and glycolipids of microbial and viral antigens, including HIV gp120. CD207 is expressed only in Langerhans cells, which are immature dendritic cells of the epidermis and mucosa, and its expression decreases during Langerhans cells maturation. Upon antigen binding CD207 localizes to the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed membranes, which leads to a nonclassical antigen-processing pathway.
Product Specifications
Gene Name
CD207
Gene ID
50489
UniProt
Q9UJ71
Host
Mouse
Reactivity
Human, Non-Human Primates
Immunogen
Fusion protein of human CD207 extracellular part and IgG Fc fragment
Target Antigen
CD207
Clonality
Monoclonal
Clone
2G3
Applications
ICC, ELISA, IHC, FACS
Purification
Purified by protein-A affinity chromatography.
Format
Purified
Components
Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Flow cytometry: Recommended dilution: 0.5-4 μg/ml. Extracellular and intracellular staining.
Isotype
Mouse IgG1 lambda
Frequently Asked Questions
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