PE conjugated Anti-Hu CD303 Mab (15E3)

Specificity:The mouse monoclonal antibody 15E3 recognizes an extracellular epitope of human CD303, a transmembrane glycoprotein expressed on plasmacytoid dendritic cells. CD303 is an approximately 38 kDa type II transmembrane glycoprotein with an extracellular C-type lectin domain. It is a specific marker of plasmacytoid dendritic cells, and plays roles in capturing of pathogen-related oligosaccharide-containing antigens by them, and in their presentation to T cells. CD303 also mediates a potent inhibition of interferon alpha/beta production in plasmacytoid dendritic cells, thus it represents a potential target for lupus erythematosus therapy.