PE conjugated Anti-Human LOX1 Mab (Clone: 15C4)

Specificity: The mouse monoclonal antibody 15C4 recognizes an extracellular epitope of LOX1, a C-type lectin transmembrane protein. LOX1, a 31 kDa type II transmembrane protein, is a C-type lectin, functioning as a scavenger receptor for e.g. oxidized low density lipoprotein, apoptotic heat shock proteins, or CRP. It is expressed by macrophages, fibroblasts, platelets, endothelial cells, and smooth muscle cells, and its defects can lead to atherosclerosis. Its expression is enhanced under inflammatory conditions. Multiple splicing variants have been identified.

Product Specifications

Product Name Alternative

OLR1, SLOX1, SCARE1, CLEC8A, oxidized low density lipoprotein receptor 1

Gene Name

OLR1

Gene ID

4973

UniProt

P78380

Host

Mouse

Reactivity

Human

Immunogen

Fusion protein of human LOX1 ectodomain and of human IgG Fc

Target Antigen

LOX1

Clonality

Monoclonal

Clone

15C4

Applications

FACS

Purification

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Components

Storage buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Applications Notes

Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.