Anti-Hu CD11b Purified
CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18) ; expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.Specificity :The mouse monoclonal antibody ICRF44 recognizes an extracellular epitope of CD11b (Mac-1alpha), a 165-170 kDa type 1 transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells.
Product Specifications
Product Name Alternative
Integrin subunit alpha M Mac-1, Integrin alpha M, ITGAM, CR3A, MO1A, MAC1A
Gene Name
ITGAM
Gene ID
3684
UniProt
P11215
Reactivity
Human, Non-human primates
Immunogen
Rheumatoid synovial cells and human monocytes.
Target Antigen
CD11b
Clonality
Monoclonal
Clone
ICRF44
Applications
FACS, IP, IHC-Fr, ICC
Purification
Purified by protein-A affinity chromatography.
Format
Purified
Components
Storage Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/mL
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
