Anti-Hu CD152 Purified
CD152 / CTLA-4 is a homodimeric transmembrane protein similar to CD28 and binding the same ligands, i.e. CD80 (B7.1) and CD86 (B7.2), but with higher affinity. Unlike CD28 with important costimulating functions, CD152 acts as an important inhibitory receptor essential for modulation of the immune system. CD152 / CTLA-4 becomes transiently expressed on activated T cells and its malfunction can cause autoimmune diseases, such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, or thyroid-associated orbitopathy.Specificity :The mouse monoclonal antibody BNI3 recognizes an extracellular domain of human CD152 / CTLA4, an approximately 45 kDa type I transmembrane protein serving as a negative regulator of T cell responses.
Product Specifications
Product Name Alternative
Cytotoxic T-lymphocyte associated protein 4 CTLA4, GSE, GRD4
Gene Name
CTLA4
Gene ID
1493
UniProt
P16410
Reactivity
Human
Immunogen
Human CD152-IgG heavy chain fusion protein
Target Antigen
CD152
Clonality
Monoclonal
Clone
BNI3
Applications
FACS, IP, IHC-Fr, ICC
Purification
Purified by protein-A affinity chromatography.
Format
Purified
Components
Concentration: 1 mg/mLStorage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Flow cytometry: Recommended dilution: 2-5 μg/mL, Intracellular staining.
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