Anti-Hu CD271 Purified

CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.Specificity :The mouse monoclonal antibody NGFR5 (originally C34C) recognizes an epitope within ammino acids 1 - 160 of CD271/NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily.

Product Specifications

Product Name Alternative

Nerve growth factor receptor TNFRSF16, NGFR, p75NTR, p75NGFR

Gene Name

NGFR

Gene ID

4804

UniProt

P08138

Reactivity

Human, Rabbit, Cat, Non-human primates, Ferret

Immunogen

Purified CD271 protein isolated from human melanoma cell line A875

Target Antigen

CD271

Clonality

Monoclonal

Clone

NGFR5

Applications

FACS, IP, WB, IHC, ICC, MC

Purification

Purified by protein-A affinity chromatography.

Format

Purified

Components

Concentration: 1 mg/mLStorage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage Conditions

Store at 2-8°C. Do not freeze.

Applications Notes

Immunohistochemistry (paraffin sections) : Recommended dilution: 1-2 μg/mL; Positive tissue: melanoma, heat-mediated antigen retrieval. Flow cytometry: Extracellular and intracellular staining; recommended dilution: 1-4 μg/mL.