Anti-PCNA Purified
PCNA (proliferating cell nuclear antigen) is the DNA polymerase delta auxiliary protein acting in homotrimeric form to increase the processivity of leading strand synthesis during DNA replication. PCNA is expressed in the nucleus of all proliferating cells. In response to DNA damage, it is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. PCNA is a useful marker of DNA synthesis, as its form not involved in DNA synthesis degradates in histological preparations in the presence of organic solvents.Specificity :The mouse monoclonal antibody PC10 (also known as 3F81) recognizes PCNA, a 36 kDa conserved nuclear protein serving as a cofactor for DNA synthesis.
Product Specifications
Product Name Alternative
Proliferating cell nuclear antigen ATLD2
Gene Name
PCNA
Gene ID
5111
UniProt
P12004
Reactivity
Mouse, Human, Non-human primates, Drosophila, Chicken, Rat
Immunogen
Recombinant rat PCNA
Target Antigen
PCNA
Clonality
Monoclonal
Clone
PC10
Applications
FACS, IP, WB, IHC, IHC-Fr, ICC
Purification
Purified by protein-A affinity chromatography.
Format
Purified
Components
Concentration: 1 mg/mLStorage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.
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