Anti-Mouse CD49d PE (Clone : R1-2)
CD49d (integrin alpha 4), also known as very late antigen 4 alpha (VLA-4 alpha) is a cell surface glycoprotein constituting integrin complexes. CD49d heterodimerizes with CD29 (integrin beta 1) to form VLA-4 antigen, which is involved in cell-cell and cell-extracellular matrix interactions, which is a receptor for CD106 (VCAM) and fibronectin. CD79d also heterodimerizes with integrin beta 7 to form LPAM-1, which binds to MAdCAM-1 (mucosal vascular addressin) . These interactions are important for cell adhesion and activation.Specificity : The rat monoclonal antibody R1-2 recognizes an extracellular epitope of murine CD49d / Integrin alpha 4 (VLA-4 alpha), an approximately 150 kDa glycoprotein of the integrin family, expressed on multiple blood cell types.
Product Specifications
Product Name Alternative
Itga4, Vla-4 alpha, integrin subunit alpha 4
Gene Name
Itga4
Gene ID
16401
Reactivity
Mouse
Immunogen
Murine T lymphoma line TK1
Target Antigen
CD49d
Clonality
Monoclonal
Clone
R1-2
Applications
FACS
Purification
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Components
0.5 mg/mLFormulation : Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage Conditions
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Isotype
Rat IgG2b kappa
Conjugate
PE
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