Anti-TNAP PE (Clone : W8B2B10)
Tissue non-specific alkaline phosphatase (TNAP), also known as liver/bone/kidney alkaline phosphatase, or MSCA-1 (mesenchymal stem cell antigen 1) is a selective marker for the prospective isolation of bone marrow-derived mesenchymal stem cells and mesenchymal stem-like cells. It is expressed at high levels in liver, bone, kidney, or endometrium, as well as on embryonic stem cells (ESCs) . TNAP also plays a role in bone mineralization. Mutations in TNAP gene are associated with hypercalcemia and skeletal defects (hypophosphatasia) . Specificity : The mouse monoclonal antibody W8B2B10 recognizes TNAP (tissue non-specific alkaline phosphatase), an ectoenzyme expressed mainly on embryonic stem cells, liver, bone, and kidney cells. This antibody is suitable for characterization of bone marrow-derived MSCs, iPSCs, and ESCs.
Product Specifications
Product Name Alternative
Tissue Non-specific Alkaline Phosphatase, MSCA-1, liver/bone/kidney alkaline phosphatase, alkaline phosphatase, biomineralization associated
Gene Name
ALPL
Gene ID
249
Reactivity
Human
Immunogen
WERI-RB-1 retinoblastoma cell line
Target Antigen
TNAP
Clonality
Monoclonal
Clone
W8B2B10
Applications
FACS
Purification
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Components
0.1 mg/mLFormulation : Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Storage Conditions
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Isotype
Mouse IgG1
Conjugate
PE
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