PE Conjugated, Anti-CD105 / Endoglin Monoclonal Antibody (Clone:MEM-229)
CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Product Specifications
Product Name Alternative
ENG||END
Gene Name
ENG
Gene ID
2022
UniProt
P17813
Host
Mouse
Reactivity
Pig, Human
Immunogen
Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
Target Antigen
CD105
Clonality
Monoclonal
Clone
MEM-229
Applications
FACS
Storage Conditions
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Applications Notes
Isotype
Mouse IgG2a
Conjugate
PE
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD54 / ICAM-1 (15.2), CF640R conjugate, 0.1mg/mL
