Anti-CD18 / Integrin beta2 subunit Monoclonal Antibody (Clone:MEM-48) -FITC Conjugated
CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18) . In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.
Product Specifications
Product Name Alternative
ITGB2||CD18||MFI7
Gene Name
ITGB2
Gene ID
3689
UniProt
P05107
Host
Mouse
Reactivity
Human
Immunogen
Leukocytes of a patient suffering from a LGL-type leukemia.
Target Antigen
CD18
Clonality
Monoclonal
Clone
MEM-48
Applications
FACS, IP, WB, IHC, IHC-Fr, Functional Assay
Storage Conditions
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Isotype
Mouse IgG1
Conjugate
FITC
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