Biotin Conjugated, Anti-CD105 / Endoglin Monoclonal Antibody (Clone:MEM-229)
CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Product Specifications
Product Name Alternative
ENG||END
Gene Name
ENG
Gene ID
2022
UniProt
P17813
Host
Mouse
Reactivity
Pig, Human
Immunogen
Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
Target Antigen
CD105
Clonality
Monoclonal
Clone
MEM-229
Applications
ICC, IHC, FACS, WB
Components
1mg/mL, antibody suspended in phosphate buffered saline (PBS) solution containing 0.2% BSA and 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Flow cytometry: Recommended dilution: 8 μg/ml; positive control: Kg1 human acute myelogenous leukemia cell line.
Isotype
Mouse IgG2a
Conjugate
Biotin
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