Anti-CD11b / Mac-1 alpha Monoclonal Antibody (Clone:MEM-174) -APC Conjugated
CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18) ; expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.
Product Specifications
Product Name Alternative
ITGAM||CD11B||CR3A
Gene Name
ITGAM
Gene ID
3684
UniProt
P11215
Host
Mouse
Reactivity
Human
Immunogen
Human granulocytes
Target Antigen
CD11b
Clonality
Monoclonal
Clone
MEM-174
Applications
FACS
Storage Conditions
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Isotype
Mouse IgG2a
Conjugate
APC
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Sentrin 1, NT (Sentrin, GAPC Modifying Protein 1, GMP1, PIC1, PIC-1, Small Ubiquitin-related Modifier 1, SUMO1, SUMO-1, SMT3, SMT3 Homolog 3, SMT3 Suppressor of Mif Two 3 Homolog 1, SMT3C, SMT3H3, Ubiquitin Homology Domain Protein PIC1, Ubiquitin-like 1, Ubiquitin-like Protein SMT3C, Ubiquitin-like Protein UBL1, UBL1) (APC)
