Anti-CD81 Monoclonal Antibody (Clone:M38) -Low Endotoxin
CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells - e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.
Product Specifications
Product Name Alternative
CD81||TAPA1||TSPAN28
Gene Name
CD81
Gene ID
975
UniProt
P60033
Host
Mouse
Reactivity
Human
Immunogen
MOLT-4 (human T-ALL cell line)
Target Antigen
CD81
Clonality
Monoclonal
Clone
M38
Applications
FACS
Purification
Purified by protein-A affinity chromatography
Format
Low Endotoxin
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Functional application: In human MOLT-4 T-cell line the antibody M38 inhibits syncytium formation induced by coculture with human T-cell leukemia virus type 1 (HTLV-1) -positive human T-cell lines. Flow cytometry: recommended dilution: 1 μg/ml. Western blotting: recommended dilution: 1-2 μg/ml; positive control: Jurkat cells, non-reducing conditions.
Isotype
Mouse IgG1
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