Anti-CD81 Monoclonal Antibody (Clone:M38) -Low Endotoxin

CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells - e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.

Product Specifications

Product Name Alternative

CD81||TAPA1||TSPAN28

Gene Name

CD81

Gene ID

975

UniProt

P60033

Host

Mouse

Reactivity

Human

Immunogen

MOLT-4 (human T-ALL cell line)

Target Antigen

CD81

Clonality

Monoclonal

Clone

M38

Applications

FACS

Purification

Purified by protein-A affinity chromatography

Format

Low Endotoxin

Storage Conditions

Store at 2-8°C. Do not freeze.

Applications Notes

Functional application: In human MOLT-4 T-cell line the antibody M38 inhibits syncytium formation induced by coculture with human T-cell leukemia virus type 1 (HTLV-1) -positive human T-cell lines. Flow cytometry: recommended dilution: 1 μg/ml. Western blotting: recommended dilution: 1-2 μg/ml; positive control: Jurkat cells, non-reducing conditions.