Anti-CD279 / PD-1 Monoclonal Antibody (Clone:EH12.2H7) -Low Endotoxin
CD279 / PD-1 (programmed cell death 1), a transmembrane protein of CD28/CTLA-4 family. It is expressed inducibly mainly on activated T, B, and myeloid cells and plays a role in maintaining peripheral self-tolerance. Binding to its receptors CD273 and CD274 is associated with inhibition of T cell proliferation and induction of their anergy. It is also expressed during thymic development. Some variants of CD279 are associated with susceptibility to systemic lupus erythematosus, type 1 diabetes, and rheumatoid arthritis.
Product Specifications
Product Name Alternative
PDCD1||PD1
Gene Name
PDCD1
Gene ID
5133
UniProt
Q15116
Host
Mouse
Reactivity
Human, Non-Human Primates
Target Antigen
CD279 / PD-1
Clonality
Monoclonal
Clone
EH12.2H7
Applications
FACS, IHC-Fr, Functional Assay
Purification
Purified by protein-A affinity chromatography
Format
Low Endotoxin
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Flow Cytometry Immunohistochemistry (frozen sections) Functional Application blocking
Isotype
Mouse IgG1
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