Anti-CD146 Monoclonal Antibody (Clone:P1H12) -APC Conjugated

CD146, also known as MCAM (melanoma cell adhesion molecule) or MUC18, is a heavily glycosylated transmembrane glycoprotein with more than 50% of the mass from carbohydrates. It is expressed on epithelial and endothelial cells, fibroblasts, multipotent mesenchymal stromal cells, activated T cells and activated keratinocytes, and on some cancer cells, especially melanoma. The presence of CD146 on circulating blood cells has been confined to the activated T cells rather than circulating endothelial cells. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration.

Product Specifications

Product Name Alternative

MCAM||MUC18

Gene Name

MCAM

Gene ID

4162

UniProt

P43121

Host

Mouse

Reactivity

Dog, Mouse, Human, Rabbit

Immunogen

Cultured human umbilical cells

Target Antigen

CD146

Clonality

Monoclonal

Clone

P1H12

Applications

FACS

Components

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide.

Storage Conditions

Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.

Applications Notes

Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.