Anti-CD266 / TWEAK R Monoclonal Antibody (Clone:ITEM-4)
CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.
Product Specifications
Product Name Alternative
TNFRSF12A||FN14
Gene Name
TNFRSF12A
Gene ID
51330
UniProt
Q9NP84
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Human CD266-transfected P815 cells
Target Antigen
CD266 / TWEAK R
Clonality
Monoclonal
Clone
ITEM-4
Applications
FACS, WB, IHC-Fr, Functional Assay
Purification
Purified by protein-A affinity chromatography
Format
Purified
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Flow Cytometry Western Blotting Immunohistochemistry (frozen sections) Functional Application blocking
Isotype
Mouse IgG2b
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