Anti-CD45R Monoclonal Antibody (Clone:RA3-6B2)

CD45R, also known as B220, is a receptor-type protein tyrosine phosphatase glycoprotein. It is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45R expression also identifies a subset of murine bone marrow cells able to form osteoclast-like cells.

Product Specifications

Host

Rat

Reactivity

Human, Mouse, Feline

Immunogen

Abelson murine leukemia virus-induced pre-B tumor cells

Target Antigen

CD45R (human, mouse)

Clonality

Monoclonal

Clone

RA3-6B2

Applications

FACS, IP, IHC, IHC-Fr, ICC, Functional Assay

Purification

Purified by protein-G affinity chromatography

Format

Purified

Storage Conditions

Store at 2-8°C. Do not freeze.

Applications Notes

Flow Cytometry Immunoprecipitation Immunohistochemistry Immunohistochemistry (frozen sections) Immunocytochemistry Functional Application modulation of B cell responses