Anti-CD105 Monoclonal Antibody (Clone:MJ7/18)
CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Product Specifications
Product Name Alternative
Eng||Edg
Gene Name
Eng
Gene ID
13805
UniProt
Q63961
Host
Rat
Reactivity
Mouse
Immunogen
Inflamed mouse skin
Target Antigen
CD105 (mouse)
Clonality
Monoclonal
Clone
MJ7/18
Applications
IP, FACS, WB
Purification
Purified by protein-G affinity chromatography
Format
Purified
Components
1mg/mL, Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Isotype
Rat IgG2a, kappa
Conjugate
Unconjugated
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