Anti-LARGE1 Monoclonal Antibody (Clone:LARGE-02)
LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.
Product Specifications
Product Name Alternative
LARGE1||KIAA0609||LARGE
Gene Name
LARGE1
Gene ID
9215
UniProt
O95461
Host
Mouse
Reactivity
Human
Immunogen
Recombinant fragment of human LARGE1 (amino acids 35-142)
Target Antigen
LARGE1
Clonality
Monoclonal
Clone
LARGE-02
Applications
FACS, WB
Purification
Purified by protein-A affinity chromatography
Format
Purified
Storage Conditions
Store at 2-8°C. Do not freeze.
Isotype
Mouse IgG2b
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