Anti-ABRA1 Monoclonal Antibody (Clone:ABRA1-01)

ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.

Product Specifications

Product Name Alternative

ABRAXAS1||ABRA1||CCDC98||FAM175A||UNQ496/PRO1013

Gene Name

ABRAXAS1

Gene ID

84142

UniProt

Q6UWZ7

Host

Mouse

Reactivity

Human

Immunogen

Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag

Target Antigen

ABRA1

Clonality

Monoclonal

Clone

ABRA1-01

Applications

FACS

Purification

Purified by protein-A affinity chromatography

Format

Purified

Components

1 mg/mL; Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Storage Conditions

Store at 2-8°C. Do not freeze.

Isotype

Mouse IgG

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