Anti-Grb2 Polyclonal Antibody
Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling.
Product Specifications
Product Name Alternative
GRB2||ASH
Gene Name
GRB2
Gene ID
2885
UniProt
P62993
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217) .
Target Antigen
Grb2
Clonality
Polyclonal
Applications
WB
Purification
Purified from rabbit serum by affinity chromatography
Format
Purified
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Western Blotting Recommended dilution: 1 μg/mL Positive control: RAMOS human Burkitt lymphoma cell line
Isotype
Rabbit IgG
Frequently Asked Questions
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